I've been taking seroquel for more than 8 years now. For the first 5 years I took seroquel with other mood stabilizers such as abilify, lamictal, risperdal and more. Seroquel has been the most effective medicine for me to stable my bipolar disorder. After taking seroquel for more than 5 years I was first introduced to seroquel XR. It's an extended release of seroquel which makes you less drowsy in the morning. I didn't know I had to take this medicine 2 hours before bed time at first so I took it 30 minutes prior to going to sleep, like how I did with regular seroquel. I couldn't fall a sleep for while and since I already took it late at night, the next morning I felt more sleepy. Because of that, I didn't like the first experience. The next time I saw my doctor I told her I didn't like it so we took it off and went back to regular seroquel for while. After one year my doctor suggested seroquel XR again but this time she told me to take it 2 hours before my actual bed time. I hesitated at first because of my bad experience, but I decided to give it a try again. This medicine kicked in as soon as I took it! However, it wouldn't make me sleepy right away like normal seroqule. It actually gave me between 2 to 2.5 hours before it made me feel like going to sleep. The next morning I felt less sleepy. I really liked having extra time at night and less tiredness in the morning. I felt like a normal person this time. I've been on seroquel XR for 3 years and I love how it works in my brain. I would not go back to regular seroquel.